摘要：目的 采用网络药理学的方法对复方苁蓉益智胶囊的主要活性成分、作用靶点、信号通路及对阿尔茨海默病的作用进行关联性探讨，预测该药在阿尔茨海默病治疗中的分子作用机制。方法 从中药系统药理学数据库（TCMSP，http://www.tcmspw.com/tcmsp.php）检索复方苁蓉益智胶囊的中药成分 (荷叶、肉苁蓉和漏芦)及从文献中获得制首乌的化学成分，并从OMIM数据库获取阿尔茨海默病靶基因，在STRING数据库构建核心化合物-靶点网络，使用CytoscapeV 3.7.2对STRING的PPI进行分析。结果 TCMSP数据库筛选出24个化合物。制何首乌文献中获得10个化合物，一共入组34个化合物。通过TCMSP和SwissTargetPredictiong数据库获得34种活性化合物潜在靶标438个。与AD相关的182个靶基因进行比对交集后，最终获得了23个交集基因，经GO富集分析和KEGG通路富集分析，筛选出34种核心组分、23个疾病相关靶点和排名前20条KEGG通路富集。 结论 复方苁蓉益智胶囊治疗阿尔茨海默病主要通过调节神经递质水平、AGE-RAGE信号通路（KEGG），参与抗炎抗氧化、神经保护等作用，为阿尔茨海默病的临床治疗提供了科学依据。

Objective To use the method of network pharmacology to explore the correlation between the main active ingredients, targets of action, signal pathways and the effect on Alzheimer''s disease of compound congrong yizhi capsules, and to predict the molecular mechanism of the drug in the treatment of Alzheimer''s disease. Methods The traditional Chinese medicine system pharmacology database (TCMSP, http://www.tcmspw.com/tcmsp.php) was used to retrieve the traditional Chinese medicine components (lotus leaf, cistanche and louver) of compound congrong yizhi capsules and the chemical composition of polygonum multiflorum，and Alzheimer’s disease target genes were obtained from the OMIM database, the core compound-target network was constructed in the STRING database, and the PPI of STRING was analyzed using CytoscapeV 3.7.2. Results TCMSP database screened 24 compounds,10 compounds were obtained from the literature on the preparation of polygonum multiflorum, and a total of 34 compounds were included in the group. 438 potential targets of 34 active compounds were obtained through TCMSP and SwissTargetPredictiong databases. After comparison and intersection of 182 target genes related to AD, 23 intersection genes were finally obtained. After GO enrichment analysis and KEGG pathway enrichment analysis, 34 core components, 23 disease-related targets and the first 20 KEGG pathways were screened out . Conclusion compound Compound Congrong Yizhi Capsules in the treatment of Alzheimer''s disease mainly regulate neurotransmitter levels, AGE-RAGE signaling pathway (KEGG), and participate in anti-inflammatory, antioxidant, and neuroprotective effects. It is a scientific basis on a clinical treatment of Alzheimer''s disease.