[摘要] 目的 探讨分析医院2019年1月1日至2020年11月30日血液感染致病菌的分布和耐药趋势，为临床医师选择适当抗菌药物治疗血液感染提供有效的参考依据。方法 运用仪器法检测致病菌对测定药物的耐药性,分析我院2019年1月1日至2020年11月30日血液培养所收集到的致病菌菌株进行比较系统地分析。结果 根据所培养得到的致病菌956株,它们中包括了，酵母样真菌24株（2.5%）、革兰阴性菌514株(53.8%)和革兰阳性菌418 株(43.7%),所有培养分离得到的致病菌中，比例最大的是大肠埃希菌,共286株(30.0%),人葡萄球菌148株(15.5%)位居第二位，还有金葡菌66株(6.8%)和屎肠球菌49株(5.2%)；耐苯唑青霉素金黄色葡萄球菌和耐苯唑青霉素凝固酶阴性葡萄球菌的检出率，分别是42.4%和74.2%。大肠埃希菌对喹诺酮类抗菌药物的耐药率在65%以上。结论 发现在医院患者血液感染里面，以葡萄球菌和大肠埃希菌以及肺炎克雷菌属居多；所以临床大夫一定要根据细菌药敏报告的结果去合理选择使用抗菌药物。

[Abstract] Objective To provide reference data for clinicians in treatment of bacterial blood infection through investigating the distribution and antimicrobial susceptibility profiles of pathogenic bacteria isolated from blood samples from the inpatients from January 1, 2019 to November 30, 2020,. Methods Instrumental method was used to test the antimicrobial susceptibility of the bacterial isolates to analyze the isolates from blood samples of the inpatients between January 1,2019 and November 30,2020. Results A total of 956 isolates were separated during this study,which were composed of 418 isolates of gram positive bacteria(43.7%),514 isolates of gram negative bacteria(53.8%) and 24 isolates of candida species(2.5%).Among these isolates,the most isolated bacteria was E.coli(286,30.0%),followed by Staphylococcus aureus subspecies(148,15.5%),Klebsiella spp(93,9.7%),staphylococcus aureus(66,6.8%) and Enterococcus species(49,5.2%).The isolation rate of oxacillin resistant staphylococcus aureus and coagulase negative staphylococci were42.4% and 74.2%.No vancomycin resistant staphylococcus aureus strains was isolated. The resistance rate of E.coli to fluoroquinolones was higher than 65%. Conclusions The most isolated bacterial pathogens separated from blood samples were E.coli,staphylococci and Klebsiella spp.The resistance rates to cephalosporins and fluoroquinolones were significantly higher.Rational antimicrobials should be selected based on the drug susceptibility test report.