目的：探讨2型糖尿病骨折患者肿瘤坏死因子-α（TNF-α）上调机制，为研究2型糖尿病患者炎症因子及趋化因子在骨折愈合过程中的作用垫定基础。 方法：随机将我院收治的患者分为2型糖尿病骨折组28例，非2型糖尿病骨折组25例和糖尿病非骨折组22例。采用酶联免疫吸附法分别测定三组患者入院时血浆中hs-CRP(血清C反应蛋白),TNF-α,IL-1β（白细胞介素-1β）,IL-6（白细胞介素-6）, IL-8（白细胞介素-8），RANTES（血清调节活化正常T细胞表达和分泌因子），IP-10（干扰素诱导蛋白10）和MCP-1（单核细胞趋化蛋白1）的含量并进行统计分析。 结果：入院时对三组患者的基线资料在性别、年龄、体重指数、患病时间和空腹血糖水平均进行比较，三组间各项指标间差异均无统计学意义。血清hsCRP，TNF-α,IL-1β，IL-6，IP-10 ，RANTES ，IL-8,和MCP-1的水平均为2 型糖尿病骨折组高于糖尿病非骨折组和骨折非糖尿病组，组间比较差异均有统计学意义。 结论：2型糖尿病骨折患者炎症因子和趋化因子的上调可能是影响骨折延迟愈合甚至不愈合的重要因素。

Object：To explore the mechanism of up-regulation of TNF-α in patients with T2DM fractures, and to lay the foundation for studying the role of inflammatory factors and chemokines in the process of fracture healing in patients with T2DM fractures. Methods：The patients in our hospital were randomly divided into 3 groups: 28 cases in the T2DM fracture group, 25 cases in the non- diabetic fracture group, and 22 cases in the T2DM non-fracture group. Enzyme-linked immunosorbent assay was used to determine the plasma levels of hs-CRP, TNF-α, IL-1β, IL-6, IL-8, RANTES, IP-10, and MCP-1 in the three groups of patients and statistical analysis. Results：The three groups of patients On admission were compared at baseline average gender, age, body mass index, fasting blood glucose and sick time, among the indicators showed no significant difference among the three groups. The levels of hsCRP, TNF-α, IL-1β, IL-6, IP-10, RANTES, IL-8, and MCP-1 are all higher in the T2DM fracture group than T2DM non-fracture group and the fracture non-diabetic group,there were significant differences between groups. Conclusion：The up-regulation of inflammatory factors and chemokines in patients with T2DM fractures may be important factors affecting the delayed union or even nonunion of fractures