目的：探讨前列腺素合成酶D2在肺癌发生发展和淋巴细胞浸润相关免疫反应中的作用。方法：通过生物信息学分析和肺癌组织芯片中前列腺素合成酶D2在不同临床分期表达水平进行检测。结果： PTGDS在肺鳞癌和肺腺癌中的低表达，p<0.001；肺腺癌以及肺鳞癌中DC细胞浸润程度较高，肺腺癌中B细胞以及CD4+T细胞浸润程度与PTGDS表达量呈正相关。结论：PTGDS在肺癌微环境中的表达模式提示，其在肺癌发生发展和淋巴细胞免疫反应中发挥重要作用。

Abstract：Objective：Objective to investigate the role of prostaglandin synthetase D2 in the development of lung cancer and immune response. Methods：the expression levels of PTGDS in different clinical stages were detected by bioinformatics analysis and tissue microarray. Results：the expression of PTGDS was low in lung squamous cell carcinoma and lung adenocarcinoma (P < 0.001); The infiltration degree of DC cells was higher in lung adenocarcinoma and lung squamous cell carcinoma. The infiltration degree of B cells and CD4 + T cells in lung adenocarcinoma was positively correlated with the expression of PTGDS. Conclusion：the expression pattern of PTGDS in lung cancer microenvironment suggests that PTGDS plays an important role in the development of lung cancer and lymphocyte immune response.

内蒙古医科大学科技百万工程(YKD2017KJBW(LH)012)内蒙古自然科学基金(2017MS(LH)0832)