肌肉生长抑制因子Myostatin由肌细胞分泌,是肌肉生长和再生的负调节因子。在本文中,我们探讨了Myostatin在骨骼代谢、骨骼生物力学和肌肉发展过程中,影响骨质疏松症的原因,以及在骨骼代谢过程中的复杂变化。例如在体外实验中,Myostatin抑制成骨细胞的分化并以剂量依赖的方式刺激破骨细胞的活性。缺少Myostatin的小鼠破骨细胞数量减少,皮质厚度增加,胫骨皮质组织矿物质密度增加。胫骨中的皮质骨密度增加,而椎体骨密度增加。虽然肌肉骨骼系统是最常见的增龄性退化的主要原因,但是骨质疏松症究其原因,在于骨重建的基本过程如骨形成和骨吸收的精密程序化过程中,成骨细胞与破骨细胞的分化或功能如何是骨代谢平衡的重要因素。另外,Myostatin对于人类骨质疏松症和肌少症中的转化应用的探索仍有相应复杂性和进一步需求。

Myostatin is a myokine, secreted by myoblasts and is a negative regulator of muscle growth and regeneration. In this paper, we explore the role of Myostatin affects osteoporosis during skeletal metabolism, skeletal biomechanics and muscle development, as well as the complex changes during skeletal metabolism. In vitro, for example, Myostatin inhibits osteoblast differentiation and stimulates osteoclast activity in a dose-dependent manner. Myostatin-deficient mice showed reduced osteoclast numbers, increased cortical thickness, and increased mineral density of tibial cortical tissue. Cortical bone density was increased in the tibia, while vertebral bone density was increased. Although the musculoskeletal system is the most common major cause of ageing degeneration, osteoporosis is explained by how the differentiation or function of osteoblasts and osteoclasts is an important factor in the balance of bone metabolism during the sophisticated programming of basic processes of bone reconstruction such as bone formation and bone resorption. However, the exploration of the translational application of Myostatin in human osteoporosis and sarcopenia still has corresponding complexity and further needs.

R589.5

内蒙古自然科学基金(2018MS08111)