[关键词]
[摘要]
目的:测定内蒙古地区蒙古族与汉族甲状腺乳头状癌(papillary thyroid carcinoma,PTC)患者BRAF V600E突变率及分布情况,进而评估基因突变与临床病理特征的关系。方法:从内蒙古医科大学附属医院甲乳外科及病理科收集2017-1~2019-12行手术治疗的20例汉族与40例蒙古族甲状腺乳头状癌患者的临床资料及存档石蜡组织进行基因检测及分析。结果:蒙古族PTC患者BRAF V600E突变率显著高于汉族患者(P<0.05)。蒙古族BRAF V600E突变与PTC患者是否合并桥本、淋巴结转移及被膜侵犯有关,而与年龄、性别、肿瘤直径、病灶数目、有无钙化无关。结论:内蒙古地区蒙古族与汉族BRAF V600E突变率不同,蒙古族患者BRAF V600E突变与PTC患者是否合并桥本、淋巴结转移及被膜侵犯有关,这些发现可为PTC患者手术方案的制订及预后评估提供参考。
[Key word]
[Abstract]
Objective: To determine the mutation rate and distribution of BRAF V600E in Mongolian and the Han nationality of patients with papillary thyroid carcinoma (PTC) in Inner Mongolia, and to evaluate the relationship between gene mutation and clinicopathological characteristics. Methods: The clinical data of 20 the Han nationality of patients and 40 Mongolian patients with papillary thyroid carcinoma who underwent surgical treatment from January 2017 to December 2019 were collected and analyzed from the Department of Thyroid Breast Surgery and Pathology, Affiliated Hospital of Inner Mongolia Medical University. Results: The mutation rate of BRAF V600E in Mongolian PTC patients was significantly higher than that in the Han nationality of patients (P<0.05). Mongolian BRAF V600E mutation was associated with the Hashimoto"s, lymph node metastasis and capsular invasion in PTC patients, but not with age, gender, tumor diameter, number of lesions, and calcification. Conclusion: The mutation rate of BRAF V600E in Mongolian and Han nationalities in Inner Mongolia is different. BRAF V600E mutation in Mongolian patients is related to whether PTC patients have the Hashimoto"s, lymph node metastasis and capsular invasion. These findings can provide reference for the formulation of surgical plans and prognosis evaluation of PTC patients.
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[基金项目]
自然科学一般研究项目(NJZY18102)