目的：建立GC内标法同时测定复方樟脑乳膏中樟脑、薄荷脑、水杨酸甲酯主要成分的含量。方法：采用SHIMADZU SH-Rtx-Wax毛细管色谱柱（30 m × 0.25 mm × 0.25 μm），载气为氮气，流速 1 mL·min-1，空气流速 200 mL·min-1，氢气流速 32 mL·min-1，FID为检测器，检测器温度250 ℃，进样口温度250 ℃，分流比10:1，程序升温（起始温度为 160 ℃，维持 13.5分钟，以每分钟 60 ℃的速率升温至 240 ℃，维持 15分钟），正十三烷为内标。结果：复方樟脑乳膏中樟脑、薄荷脑、水杨酸甲酯分离度良好，方法专属性强，线性范围宽，精密度好，准确度高，耐用性好。樟脑、薄荷脑、水杨酸甲酯分别在 0.89 mg· mL-1 ~ 1.85 mg· mL-1（r = 0.999 9）、0.75 mg· mL-1 ~ 1.70 mg· mL-1（r = 0.999 0）、0.38 mg· mL-1 ~ 1.33 mg· mL-1（r = 0.999 8）浓度范围内与其峰面积及内标溶液峰面积的比值呈线性关系，低、中、高浓度平均回收率分别为 100.5 %（RSD = 0.7 %）、99.9%（RSD = 0.9%）、102.3%（RSD = 1.0%）。结论：该方法操作简单，准确度高，重现性好，可用于复方樟脑乳膏的质量控制。

Objective: To establish a method for the determination of camphor、Menthol and Methyl Salicylate in compound camphor cream by GC internal standard method. Methods：GC method was performed on SHIMADZU SH-Rtx-Wax capillary column (30 m × 0.25 mm × 0.25 μm) column，with nitrogen as the carrier gas，the flow rate was 1. 0 mL·min-1，air 200 mL·min-1，hydrogen 32 mL·min-1，and FID as the detector（temperature is 250 ℃），Injector temperature is 250 ℃，split ratio 10:1.The temperature programme: Initial temperature was 160 ℃，which was retained 13.5 minutes，and then 60 ℃ per minute up to 240 ℃，retaining 15 minutes. N-tridecane was used as the internal standard. Results: Camphor，menthol，methyl salicylate，n-tridecane and various accessories in compound camphor cream were well separated．The method was specific，linear，accurate，precise and robust．The linear ranges of camphor、Menthol and Methyl Salicylate were 0.89 mg· mL-1 ~ 1.85 mg· mL-1 (r = 0.999 9),0.75 mg· mL-1 ~ 1.70 mg· mL-1 (r = 0.999 0),0.38 mg· mL-1 ~ 1.33 mg· mL-1 (r = 0.999 8), respectively．The average recoveries(n = 3) of low,middle and high concentrations were 100.5%（RSD = 0.7%）、99.9%（RSD = 0.9%）、102.3%（RSD = 1.0%） Conclusion：The method was simple with high accuracy and good reproducibility, and provides a reliable way for evaluating the quality of compound camphor cream.