【摘要】目的 研究鼠神经生长因子联合常规的运动康复训练对脑出血患者运动功能恢和脑源性神经营养因子的影响，为临床患者提供新的治疗措施。方法 选择2018年1月～2019年10月内蒙古医科大学附属医院康复科收治的60例脑出血患者进行随机分组，干预组在常规的运动康复训练基础上注射鼠神经生长因子，对照组仅接受常规的运动康复训练，比较两组患者治疗前后Fugl-Meyer运动功能评分、Barthel指数、改良Ashworth痉挛量表 (MAS)及血清脑源性神经营养因子（brain-derived neurotrophic factor，BDNF）。结果 治疗3周后两组患者Fugl-Meyer运动功能评分和Barthel指数明显改善, 且干预组改善程度明显优于对照组，组间差异具有统计学意义（ p ＜0.01），而改良Ashworth痉挛量表 (MAS)在两组间无明显统计学差异。治疗3周后两组患者血清BDNF含量均增高( p ＜0.01) , 但干预组增高程度明显优于对照组(p ＜0.01) 。结论 鼠神经生长因子联合康复训练改善脑出血患者运动功能恢复可能是通过增加脑源性神经营养因子含量的途径发挥作用。

【Abstract】Objective To investigate the effects of mouse nerve growth factor (mNGF) combined with routine exercise rehabilitation training on motor function and brain-derived neurotrophic factor in patients with intracerebral hemorrhage, and to provide new treatment measures for clinical patients. Methods A total of 60 patients with intracerebral hemorrhage admitted to the Rehabilitation Department of the Affiliated Hospital of Inner Mongolia Medical University from January 2018 to October 2019 were randomly divided into two groups. The intervention group was injected with rat nerve growth factor on the basis of conventional exercise rehabilitation training, while the control group only received conventional exercise rehabilitation training. The Fugl-Meyer Motor Function Assessment, Barthel Index, Modified Ashworth Spasticity Scale (MAS) and serum brain-derived neurotrophic factor (BDNF) were compared between the two groups before and after treatment. Results After 3 weeks of treatment, Fugl-Meyer Motor Function Assessment and Barthel Index of the two groups were significantly improved, and the improvement degree of the intervention group was significantly better than that of the control group, and the difference between the two groups was statistically significant (P < 0.01). The Modified Ashworth Spasticity Scale (MAS) had no significant difference between the two groups. After 3 weeks of treatment, the content of brain-derived neurotrophic factor (BDNF) increased in both groups (P < 0.01), but the increase degree in the intervention group was significantly better than that in the control group (P < 0.01). Conclusion The mouse nerve growth factor combined with rehabilitation training can improve the recovery of motor function in patients with intracerebral hemorrhage by increasing the content of brain-derived neurotrophic factor.