【摘要】目的 腹膜透析（PD）治疗开始时的残余肾功能（RRF）可以预测稳定期PD患者的生存率。本研究目的是分析PD患者基线RRF对患者生存率的影响。方法 收集204例PD患者，根据其初期的尿量分为两组：无尿组（尿量≤100毫升/天）和有尿组（尿量>100毫升/天），分析其人口统计学特征、基线数据、实验室参数和生存率。结果 无尿患者59例，平均随访时间为41.1±27.9月；有尿患者145例，平均随访期38.8±25.9个月。23名患者之前接受过血液透析（HD）治疗。治疗开始时，无尿组的收缩压和舒张压低于有尿组（p<0.001），但C反应蛋白（p=0.002）和铁蛋白（p<0.001）水平较高。无尿组和有尿组腹膜炎发生率分别为1次/28.5月和1次/30.8月（p>0.05）。Kaplan-Meier生存分析显示，有尿组患者的1年、3年和5年生存率分别为94.9%、83.4%和84.5%，而无尿组患者的生存率分别为86.4%、78.5%和51.9%，其中5年生存率具有统计学意义（p<0.05）。结论 PD患者PD治疗开始时的RRF对患者生存率有重要的积极影响。有尿组和无尿组的腹膜炎发生率没有差异。 【关键词】患者生存；腹膜透析；残余肾功能 【中图分类号】R692 【文献标识码】 A 【文章编号】：

CORRELATION BETWEEN RESIDUAL RENAL FUNCTION AND SURVIVAL RATE IN PATIENTS WITH PERITONEAL DIALYSIS SUN Mingxia1 HOU Xiaoyan2* （1.Department of Nephrology and Rheumatology，Hohhot First Hospital， Hohhot 010020，China；2. Department of Nephrology, Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050，China） 【Abstract】Objective Residual renal function (RRF) at the initiation of peritoneal dialysis (PD) therapy can be a predictor of survival in stable PD patients. The aim of the present study was to investigate PD patients regarding the effect of baseline RRF on patient. Methods Urine output at the beginning of PD therapy was evaluated retrospectively in 204 PD patients. Patients were divided into two groups: patients with anuria (urine output ≤100 ml/day) and patients without anuria (urine output >100 ml/day). Results The number of patients with anuria was 59. The mean follow-up period was 41.1±27.9 months. 145 patients had no anuria, mean follow-up period 38.8±25.9 months, 23 patients had received hemodialysis( HD) therapy before. At the beginning of therapy, systolic and diastolic blood pressures were lower in patients without anuria than in patients with anuria (p<0.001), but C-reactive protein (p=0.002) and ferritin (p<0.001) levels were higher. The peritonitis rate was one episode per 28.5 versus 30.8 patient-months for the anuric and non-anuric groups, respectively (p>0.05). For Kaplan–Meier survival analysis, The 1-, 3-, and 5-year survival rates were 94.9%, 83.4%, and 84.5% in patients without anuria, respectively, whereas they were 86.4%, 78.5%, and 51.9% in patients with anuria, respectively. The 5-year survival rates according to residual volume states were statistically significant (p<0.05).Conclusions RRF at the beginning of PD has an important and positive impact on patient survival in PD patients. Peritonitis rates were not different for patients with anuria and without anuria. 【Keywords】Patient survival; Peritoneal dialysis; Residual renal function