目的: 探讨MMP－9 基因多态性与内蒙古地区COPD 人群的易感性。方法: 采用病例对照研究，应用
聚合酶链反应－限制性片段长度多态性的方法，对蒙古族186 例COPD 病人和219 例健康对照组的MMP－9 基因
1562( C/T) 位点的多态性进行检测，计算两组基因型频率及等位基因分布等。结果: MMP－91562( C/T) 的基因
型CC、TT、CT 的频率在186 例COPD 病例组中分别是50．00%、42．47%、7．53%; 在219 例健康对照组中的频率分
别是30．59%、34．70%、34．70%，C 等位基因频率在COPD 病例组与健康对照组分别是53．76%和47．95%; T 等位基
因的频率在两组中分别是46．24%和52．05%。结论: MMP－9 基因多态性与内蒙古地区蒙古族COPD 具有易感
性，1562( C/T) 基因型与蒙古族COPD 发病密切相关。

Objective: To explore whether the matrix metalloproteinases－9( MMP－9) polymorphism
was associated with COPD in population of Inner Mongolia．Methods: Case－Control study was employed
and 186 COPD and 219 control subjects were selected．Genotyping was determined by using PCRRFLP
both in case and controls Subjects．Results: The frequencies of genotype CC，TT and CT in COPD
were 50．00%，42．47%and 7．53%respectively． In control group were 30．59%，34．70%and 34．70%respectively．
The frequencies of C allele in COPD and control group were 53．76% and 47．95%
respectively．The frequencies of T allele in two groups above were 46．24%and 52．05%respectively．Conclusion:
The genetic polymorphism of MMP － 9 ( 1562C /T) was associated with the susceptibility to
COPD in population of Inner Mongolia．

R563．3

 收稿日期: 2016－10－27; 修回日期: 2016－12－09
基金项目: 内蒙古医科大学青年创新基金( YKD 2014 QNCX013)
作者简介: 覃洁( 1979－) ，女，内蒙古医科大学附属医院呼吸内科副主任医师，医学博士。