[关键词]
[摘要]
目的:为蒙药森登进一步深入开发与应用提供参考。方法:以“森登”、“文冠木”“化学成分”、“生物活性”、“药理作用”、“临床应用”、“SENDENG”、“WEN-GUAN-MU”、 “Xanthoceras sorbifolium”、“Chemical constituents”、“Biological activities”、“Chemical constituents”、“ Therapeutic Applications”等作为关键词,在中国知网、万方、维普、PubMed、SciFinder、Web of Science等数据库中查询1986年1月-2019年12月发表的相关文献,并对其化学成分、生物活性、药理作用、临床应用进行归纳总结作一综述。结果与结论:检索得到的相关文献为246篇,其中有效文献为37篇。从森登中分离得到的化学成分,主要包括黄酮类、醌类、甾类和香豆素类化合物,其中黄酮类化合物最多。药理研究表明,森登具有抗炎、抗氧化、抗凝血和抑制艾滋病毒蛋白酶等药理活性作用,并有着广泛的临床应用。在森登质量标准及化学成分方面尚未深入研究,所以有必要进行化学成分、药理活性及其作用机制方面有待进行全面的研究,阐明其药效物质基础。
[Key word]
[Abstract]
Objective: To provide reference for the further development and application of Mongolian Medicine SENDENG. Method: "SEN DENG", "WEN GUAN MU",“Xanthoceras sorbifolium”, "Chemical Composition", "Biological Activity", "Pharmacological Activity ", " Therapeutic Applications ", "Chemical constituents" and other keywords are used to search relevant literatures published from January 1986 to December 2019 in CNKI, WANFANG, CQVIP, PubMed, SciFinder, Web of Science and other databases. A summary of the biological activities, pharmacological effects, and clinical application. Result and Conclusion: There are 246 relevant literatures retrieved, including 37 valid literatures. The chemical components isolated from SENDENG mainly include Flavonoids, Quinones, Steroids and Coumarin compounds, among which Flavonoids are the most. Pharmacological studies have shown that SENDENG has anti-inflammatory, anti-oxidant, anti-coagulant and HIV protease inhibitory activities, and has a wide range of clinical applications. There is no in-depth study on SENDENG quality standards and chemical composition. Hence, it is necessary to conduct a comprehensive study on chemical composition, pharmacological activity and its mechanism.
[中图分类号]
[基金项目]
内蒙古医科大学蒙药学“一流学科”蒙药专业研究生科研能力提升项目(myxylxkky 2019-04)